Sulbutiamine is a synthetic derivative of thiamine which can cross the blood-brain barrier much more effectively. Sulbutiamine provides a mild stimulating effect when taken, and is often used for improving mental stamina and treating erectile dysfunction.


  • Improve memory. [3][4][5]
  • Increases energy and improves focus. [1][2]
  • Improved overall mood. [8]
  • Effective for treatment of psychogenic erectile dysfunction. [6]
  • Effective for the treatment of asthenia. Asthenia is a condition of chronic fatigue that is cerebral in nature. [1][2]

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What Is Sulbutiamine?

Sulbutiamine is a synthetic derivative of vitamin B1 (thiamine). Up until the 20th century, a nervous system disorder called beriberi was very common in Japan. Beriberi causes severe lethargy and fatigue, along with complications effecting the cardiovascular, nervous, muscular, and gastrointestinal systems. People were contracting beriberi because they had a thiamine deficiency.

Due to the spread of beriberi, Japan set up a Vitamin B Research Committee. This committee led to the discovery of Sulbutiamine. Since its discovery, studies have revealed that Sulbutiamine has many nootropic properties and its uses extend far beyond the treatment of beriberi.

Medical Uses of Sulbutiamine

Sulbutiamine has a variety of clinical uses. It was developed as a treatment for beriberi and is frequently prescribed for the treatment of asthenia, a disease with cerebral origins that causes chronic fatigue. Sulbutiamine’s cognitive benefits cause it to be prescribed to improve memory in patients suffering from Alzheimer’s disease and schizophrenia.

A recent study has also shown Sulbutiamine to be effective in treating erectile dysfunction. In the study sixteen out of twenty patients found success using Sulbutiamine to treat their erectile dysfunction. This is significant because Sulbutiamine is much cheaper and safer than most drugs prescribed for this purpose.

Using Sulbutiamine

Unlike many nootropics, Sulbutiamine is not meant to be taken daily. It is not particularly dangerous to do so, but a tolerance builds quickly and will lose much of its effectiveness after a few days of consecutive use. Sulbutiamine is best used sparingly, its stimulating effect and increase in mental endurance makes it a much safer alternative to traditional stimulants, though its effects are more subtle.

How to Take Sulbutiamine

Sulbutiamine can be taken as a bulk powder or in capsules. Like with most nootropics, bulk powder Sulbutiamine is much cheaper and with the purchase of a capping machine.

Bulk powder Sulbutiamine is notorious for having an extremely foul taste, so it is strongly recommended that you dissolve it in a beverage with a strong flavor or use a capping machine to create your own pills.

Dosing Sulbutiamine

The recommended dosage for therapeutic use is 850mg per day for a 150lb person. [4] However, the manufacturer of Arcalion recommends dosages not exceeding that of 600mg per day.

Usually a 200-400 mg dose should be sufficient, however some people may want to take 600 mg. It is best to take only one dose of Sulbutiamine a day. Unless using it to treat a specific condition it is not wise to exceed 600 mg per day. Even though no serious side effects have been noticed at higher doses, taking more than 600 mg at once isn’t likely to be more effective.

How Does Sulbutiamine Work?

Sulbutiamine is a fat soluble molecule that crosses the blood-brain barrier much more easily than vitamin B1 (thiamine). Once it crosses into the brain, it is metabolized to produce thiamine. [7] Thiamine is then used by the brain to produce the neurotransmitters Acetylcholine (ACh) and GABA. [3]

Sulbutiamine also facilitates glutamatergic transmissions. Glutamate is the most common excitatory neurotransmitter in the central nervous system. It plays an important role in cognitive functions such as learning and memory. [9][10]

Finally, sulbutiamine reduces the release of dopamine in the prefontal cortex, consequently increasing the density of D1 dopamine receptors. [8]

Safety and Side Effects of Sulbutiamine

Sulbutiamine is regarded as being extremely safe. At therapeutic doses of 850mg per day only mild skin allergies have been reported. There is only report of complications which was caused by chronic overuse. [5] A patient suffering from bipolar disorder was prescribed sulbutiamine because he was suffering from lack of energy. Since he found the sulbutiamine very helpful he ceased all his other medications and began to take more than twice the daily recommended dosage. The end result was severity in his bipolar disorder symptoms. No serious issues in healthy people have arisen from use of sulbutiamine.

Sulbutiamine FAQ

Below are some of the most commonly asked questions about Sulbutiamine. If you have a question that’s not on this list, send it to us at [email protected] and we will answer it for you.

Should I Take Sulbutiamine?

Sulbutiamine is a very safe and very proven nootropic. Many people take it because it produces noticeable feelings in under an hour.

Do you want to start your morning with a smile on your face and lots of energy?

Many people take it to make their morning rush more bearable. People find they no longer need that cup of coffee in the morning. After taking just two or three doses of Sulbutiamine they have energy, feel good, and feel sharper.

Are you looking for a completely safe supplement to improve your workout?

Since Sulbutiamine increases the production of GABA, logically it would work to increase levels of human growth hormone. Even though no studies have been conducted to confirm this, many people find that the boost of energy alone helps them get in a more intense workout.

Do you want more confidence and stamina in the bedroom?

Sulbutiamine is proven to be effective for the treatment of psychological erectile dysfunction. Some people take it before a sexual experience just for the energy and the confidence. Even though it may not work for everyone, there’s no reason not to give it a shot.

The best part about Sulbutiamine, besides the noticeable effects, is its proven safety. If you have never taken nootropics before, or are a veteran user, you should definitely consider giving it a try. The results might surprise you.

How long does it take before I will feel the effects of Sulbutiamine?

Sulbutiamine acts as a mild stimulant and produces a more noticeable feeling than many other nootropics. You should feel Sulbutiamine working in less than an hour after taking it.

What nootropics possess good synergy with Sulbutiamine?

One excellent quality of Sulbutiamine is how well its effects mix with that of other nootropics. Taking Sulbutiamine with a ‘racetam regimen is an excellent way to gain additional mental stamina and greatly improve your productivity.

For more ideas on nootropics that combine well with Sulbutiamine, check out the Focus Enhancement Regimen. This is a nootropic regimen designed to help boost focus and motivation. Sulbutiamine is an optional addition to this regimen because taking it every day will cause a tolerance to develop and will cause its effects to diminish.

How long does a single dose of Sulbutiamine last?

Sulbutiamine has a half life of about 5 hours, meaning that a single dose of Sulbutiamine will last for about that long before its effects begin to diminish.

Is it possible to overdose on Sulbutiamine?

Sulbutiamine is extremely safe even at very high doses. In fact, there is only one case of complications from chronic overuse. [5] A patient suffering from bipolar disorder was prescribed Sulbutiamine to help improve his energy levels. He found the Sulbutiamine extremely effective and ceased taking his other medications and doubled his dosage of Sulbutiamine. The end result was severity in his bipolar disorder symptoms.

No serious issues in healthy people have arisen from use or overuse of Sulbutiamine.

Is it safe to drink alcohol while on Sulbutiamine?

Drinking alcohol in normal amounts while taking Sulbutiamine is completely safe. In fact anecdotal evidence suggests that drinking on Sulbutiamine may enhance the effect of alcohol and reduce hangovers the next day. Even so, if you are unsure of how you will react to alcohol while taking Sulbutiamine it is best to start very slowly.

Does Sulbutiamine make a good study drug?

Sulbutiamine is excellent as a study aid because it increases mental energy and endurance while also improving memory. In fact, Sulbutiamine is one of the best nootropics to use as an amphetamine alternative if you have large amounts of studying or work to do. While not as effective, Sulbutiamine is much safer and is less likely to cause insomnia.

Can I take Sulbutiamine every day?

While it is safe to take Sulbutiamine every day, it isn’t practical because a tolerance to its effects builds very quickly. Sulbutiamine is best used every once and awhile when an extra boost is needed.

What are some good alternatives to Sulbutiamine?

Adrafinil, and Modafinil also provide boosts in mental energy and act as mild stimulants.

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Cited Studies

1. Shah SN; Sulbutiamine Study Group (2003). “Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia”. J Assoc Physicians India 51: 891–5. PMID 14710977.

2. Levin OS, Slizkova IuB (2007). “[The use of enerion in the treatment of asthenic disorders in patients after mild cranio-cerebral trauma]“. Zh Nevrol Psikhiatr Im S S Korsakova 107 (5): 44–8. PMID 18379496.

3. Micheau J, Durkin TP, Destrade C, Rolland Y, Jaffard R (1985). “Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation”. Pharmacol Biochem Behav 23 (2): 195–8. doi:10.1016/0091-3057(85)90555-6. PMID 4059305.

4. Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). “Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task”. Prog Neuropsychopharmacol Biol Psychiatry 29 (6): 928–35. doi:10.1016/j.pnpbp.2005.04.035. PMID 15951087.

5. Ollat, H; B Laurent, S Bakchine, BF Michel, J Touchon, B Dubois (2007). “[Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease”. Encephale 33 (2): 211–15. PMID 17675917.

6. Dmitriev DG, Gamidov SI, Permiakova OV (2005). “[Clinical efficacy of the drug enerion (sulbutiamine) in the treatment of patients with psychogenic (functional) erectile dysfunction]“. Urologiia 1 (1): 32–5. PMID 15776829.

7. Bettendorff L, Weekers L, Wins P, Schoffeniels E (1990). “Injection of sulbutiamine induces an increase in thiamine triphosphate in rat tissues”. Biochem Pharmacol 40 (11): 2557–60. doi:10.1016/0006-2952(90)90099-7. PMID 2268373.

8. Trovero F, Gobbi M, Weil-Fuggaza J, Besson MJ, Brochet D, Pirot S (2000). “Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain”. Neurosci Lett 292 (1): 49–53. doi:10.1016/S0304-3940(00)01420-8.PMID 10996447.

9. Parada-Turska J, Turski WA (1990). “Excitatory amino acid antagonists and memory: effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasks”. Neuropharmacology 29 (12): 1111–6. doi:10.1016/0028-3908(90)90034-O. PMID 2149871.

10. Puma C, Baudoin C, Bizot JC (1998). “Effects of intraseptal infusions of N-methyl-D-aspartate receptor ligands on memory in an object recognition task in rats”. Neurosci Lett 244 (2): 97–100. doi:10.1016/S0304-3940(98)00137-2. PMID 9572594.