Pterostilbene is a substance that naturally occurs in grapes and berries. While it has long been renowned for it’s cardiovascular benefits, research has shown it to also be a nootropic.


  • Lowers cholesterol and fights heart disease [2][3]
  • Slows the cognitive decline and motor-skill decline brought on by aging [5]
  • Has anti-oxidant and cancer-fighting properties [6]

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What Is Pterostilbene?

Pterostilbene is a naturally occurring substance found in blueberries and grapes. It is classified as a phytoalexin meaning plants produce it to fight off various types of infections. It is well known for having various health benefits including reduction of cognitive decline due to aging, lowering cholesterol levels, and anti-cancer effects.  Agnes Rimando, a chemist at ARS’s Natural Poducts Utilization Research Laboratory in Oxford, Mississippi stated:

“The more we study Pterostilbene, the more we see its huge potential in the human health field”

Pterostilbene Dosage Information

The suggested daily dosage is between 100 to 250mg for adults. You should reach these amounts by taking a single 50 to 125mg capsule twice daily. [7]

How Does Pterostilbene Work?

Pterostilbene is known to bind to the PPAR-alpha receptor. This receptor plays a major part in the regulation of lipid metabolism in the liver and activation of this receptor promotes catabolism of fatty acids. [1]

This nootropic is known to inhibit the enzyme cytochrome P-450 which is known to activate various chemical carcinogens giving Pterostilbene anti-cancer properties.

Safety and Side Effects of Pterostilbene

This nootropic is regarded as being completely safe and there have been no reported side effects.

Pterostilbene FAQ

Below are some of the most commonly asked questions about Pterostilbene.

Should I Use Pterostilbene?

If you goal is promoting overall health then this is a nootropic you should immediately add to your regimen. It slows down the cognitive decline and motor-skill decline brought on by aging, helps keep you from getting cancer, helps with your cholesterol, and helps fight heart disease. It does all these things while having absolutely zero negative interactions and no reported side effects.

That being said, this nootropic isn’t going to make you smarter, more focused, or increase your energy in the short run. It is more a preventative nootropic then a pro-active one. If you want results now and aren’t worried about the mentioned areas of health then you might as well pass on Pterostilbene.

What Are Some Notable Pterostilbene Studies?

Scientists located at the University of Medical Science in Prozan, Poland discovered Pterostilbene as a cancer fighting compound. Their research determined that this nootropic inhibited an enzyme called “cytochrome P45” which is known to be responsible for activating certain chemical carcinogens. Rimando, one of the scientists working on the research stated, “Pterostilbene showed strong inhibitory activity, much more than resveratrol, against a particular form of cytochrome P450. This may explain the cancer-preventive property it demonstrated in a mouse mammary gland culture assay.” [6]

 The Journal of Neuroscience published an article stating that a diet high in the blueberry extract, Pterostilbene reverses mental, nerve, and muscular decline in older rats. Co-author Barbara Shukitt-Hale, PhD, a researcher at the U.S. Department of Agriculture stated What we found was that especially the blueberry diet reversed some of the age-induced deficits in motor behavior. All the diets actually helped with cognitive, or learning and memory, behavior” These rats were the equivalent of 70-75 in human years and were subjected to various Pterostilbene diets for 8 weeks. [5]

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Cited Studies

1.  Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. (June 1999). “Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.”. J Clin Invest. 103 (11): 1489–98. doi:10.1172/JCI6223. PMC 408372. PMID 10359558.



4. Pari L, Satheesh MA (July 2006). “Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats”. Life Sciences 79 (7): 641–5. doi:10.1016/j.lfs.2006.02.036. PMID 16616938

5.  Braslavsky, Andrea, “Blueberries May Be King of the Hill for Those Over the Hill,” WebMD Medical News, Sept. 16, 1999, retrieved December 29, 2006.