Pramiracetam

Pramiracetam is a powerful nootropic drug and is an extremely potent Piracetam derivative. Out of all the commonly used ‘racetams Pramiracetam is by far the most potent.

Benefits:

  • Improves the effectiveness of brain training games such as the ones offered by Lumosity.
  • Improves memory [6][7][10]
  • Improves fluid intelligence [1][2][3][5][10]
  • Improves general cognitive functions [3]
  • Helps treat and prevent Alzheimer’s disease[8][10]

What Is Pramiracetam?

Pramiracetam is yet another nootropic in the ever growing “racetam family”. If you have never heard of a “racetam” nootropic then you should read up on Piracetam first. It is the very first in the family and understanding how it works will better help you understand pramiracetam. Pramiracetam was based on piracetam but its creator claims it to be 8-30 times stronger than its predecessor. Anecdotal evidence also suggests that more people feel noticeable effects when taking pramiracetam.

It’s extremely low recommended dosage compared to the other ‘racetams attests to it’s potency. Unlike the other popular ‘racetams many people use it on an as needed basis rather than daily.

Medical Uses of Pramiracetam

Pramiracetam is a fairly new member of the ‘racetam family, and as such it is not yet well researched and is rarely used in a clinical setting. It is currently the subject of research to see how well it stacks up against other ‘racetams as a medicine. Ongoing studies are investigating its potential in treating Alzheimer’s disease and dementia.

Using Pramiracetam

Pramiracetam is one of the most powerful commonly used ‘racetams. It is said to be up to thirty times more powerful than Piracetam. Like the other ‘racetams, many people take Pramiracetam daily in order to improve their daily mental abilities. Some people only take Pramiracetam to improve their motivation to study or get alot of work done, however.

How to Take Pramiracetam

Pramiracetam capsules are difficult to find online, so taking it in bulk powder form will likely be the only option available. If you want to try Pramiracetam but prefer the convenience of capsules, consider investing in a capping machine. With this, you can easily pack bulk powder Pramiracetam into capsules that will make dosing throughout the day much easier.

Pramiracetam is fat soluble like Aniracetam, so mixing it with water or other beverages is not an effective way to take it. Placing some powder in your mouth and washing it down with a few sips of water is an easy way to take it, assuming the taste doesn’t bother you.

Dosing Pramiracetam

Doses administered during studies ranged from 75mg per day to 1,600mg per day. Keep in mind that it is far more potent than the other ‘racetams, so a dose of over 500mg is not recommended unless you find it is not effective at lower doses. As with all nootropics, it is best to start with a lower dose and work your way up if no side effects occur. Keep in mind larger doses won’t nescessarily improve the effects.

The half-life for pramiracetam ranges from 4.5-6.5 hours. This means you should take one dose in the morning and one dose 5.5 hours later.

How Does Pramiracetam Work?

Research has indicated that Pramiracetam increases Choline uptake in the brain. [1]This means that your brain uses up choline and turns it into acetylcholine (ACh) at a much faster rate. ACh is a neurotransmitter that plays a key role in many neurological functions.

ACh plays an important role in your brain’s ability to form and strengthen new connections between neurons, also known as synaptic plasticity. [2] Synaptic plasticity is closely tied with your short term memory, or working memory. The easier time your brain has creating and strengthening new connections between neurons, the easier you can create and store memories.

What’s even more interesting, is that scientists know for a fact that your working memory is closely tied with your fluid intelligence. [3][4] One recent study even revealed that a child’s working memory at 5 years of age is a better predictor of their academic success than their IQ. [5]

Safety and Side Effects of Pramiracetam

Less is known about Pramiracetam than some older ‘racetams, however like the other ‘racetams it appears to be extremely safe. In research Pramiracetam was used daily for up to 9 weeks without any adverse side effects.

A study conducted on 112 normal volunteers and 336 patients suffering from dementia revealed no adverse drug related changes. [9] All people in the study were given doses of either a single dose of 1,600mg or multiple doses ranging from 75 – 1500mg per day. These doses were administered for up to nine weeks. Side effects occured in 25% of patients taking pramiracetam and 17% of patients taking a placebo.

Common side effects may include headaches, nausea, and agitation. The headaches could be a result of choline deficieny and taking a choline supplement along with pramiracetam usually eliminates that side effect. Like the other ‘racetams, Pramiracetam shows no potential for addiction and has no withdrawal symptoms.

Pramiracetam FAQ

Below are some of the most commonly asked questions about Pramiracetam. If you have a question that’s not on this list, send it to us at [email protected] and we will answer it for you.

Should I Take Pramiracetam?

Pramiracetam belongs to a very proven family of nootropics. Many people report feeling much more “clear” when taking this nootropic. People report having an easier time remembering things and an easier time forming scentences. People taking piracetam also commonly report these effects.

Pramiracetam is known to be one of the most potent ‘racetams, so complete beginners to nootropics may want to try Piracetam first.

If you are even a little bit interested in nootropics you should go out and purchase a “racetam” along with a choline supplement immediately. Even if becoming smarter isn’t that important to you, the neuroprotective properties of the ‘racetams help keep your brain young and lower your chances for getting any form of dementia and related diseases.

With 10% of people over the age of 65 and 50% of people over the age of 85 suffering from Alzheimer’s, starting a “racetam” and choline regimen could very well keep you from slipping into dementia later on in life.[11]

How long does it take before I will feel the effects of Pramiracetam?

Unlike Piracetam, which can take weeks of use before its full benefits can be realized, most people who take Pramiracetam feel it working almost immediately. For this reason it is popular not only as a daily supplement, but as a nootropic which can be taken before a long studying or work session.

How does Pramiracetam differ from the other ‘racetams?

Pramiracetam is fat soluble like Aniracetam, and works in a similar way as all ‘racetams. The biggest difference in Pramiracetam is that it is far more potent than most other ‘racetams and works at a much smaller dose.

Can I take Pramiracetam with other ‘racetams such as Piracetam?

While little research has been performed on Pramiracetam compared to other drugs in its family, there have been no reports of adverse effects when it is taken with other nootropics. Because it is fat soluble, it may possess synergy with water soluble ‘racetams like Piracetam.

It is far more potent than other ‘racetams, however, so combining it with similar nootropics may not be necessary. It isn’t dangerous to do so though, so if using it in tandem with other ‘racetams interest you there is no reason not to try it.

Should I take Choline supplements with Pramiracetam?

While some people get enough Choline in their diets, others will need to supplement in order to avoid the side effect of mild headaches. If you experience these headaches you should supplement with Choline.

For most nootropics, it is recommended to take choline at a 2:1 ratio. Because pramiracetam is active at a much smaller dose, it would be better to take much more choline than Pramiracetam. The exact ratio of choline to Pramiracetam to take will differ from person to person and is best discovered through trial and error.

Click here to view a list of foods with high concentrations of choline.

How long does a single dose of Pramiracetam last?

The half-life for pramiracetam ranges from 4.5-6.5 hours. This means that if you take one dose in the morning you should re-dose 5.5 hours later.

Is it possible to overdose on Pramiracetam?

As with other ‘racetams, there have been no reported cases of serious adverse effects when too much Pramiracetam has been consumed. That said, there has not been much research conducted on it, and a much lower dose is required compared to other ‘racetams. For this reason you should start with small doses and work your way up slowly until the desired effects are experienced.

Is it safe to drink alcohol while on Pramiracetam?

While it is not dangerous to combine Pramiracetam and alcohol, many people report their tolerance to alcohol being dramatically reduced while on Pramiracetam. For this reason if you want to drink while taking Pramiracetam it is best to start very slowly in case you experience these effects.

Does Pramiracetam make a good study drug?

Pramiracetam’s improvement of memory and the ability to understand complex ideas mean taking Pramiracetam will make any time spent studying much more productive. In addition, anecdotal evidence suggests that taking Pramiracetam before a study session can boost focus and motivation, allowing one to study for longer without burning out.

How can I tell if Pramiracetam is working for me?

Pramiracetam is a powerful nootropic and its benefits should be felt shortly after using it. While its benefits may be hard to discern if you take Pramiracetam and watch tv, its benefits should be apparent when any mentally stimulating task is performed.

Can I take Pramiracetam every day?

Research and anecdotal evidence suggests that Pramiracetam is completely safe to take daily.

What are some good alternatives to Pramiracetam?

Pramiracetam is one of the strongest ‘racetams that is known to be completely safe and devoid of serious side effects. If you find it too potent but want similar benefits, you may be better off taking a less powerful nootropic such as Oxiracetam.

Other alternatives depend on what specific benefits you are looking for. For more information on what nootropics best meet specific needs, check out the Meet Your Goals entry on the main navigation bar at the top of this page.

Cited Studies

1. Some neurochemical properties of pramiracetam (CI-879), a new cognition-enhancing agent.

2. Focusing Effect of Acetylcholine on Neuroplasticity in the Human Motor Cortex. 

3. Improving fluid intelligence with training on working memory.

4. Working memory, fluid intelligence, and science learning. 

5. Intestigating the predictive roles of working memory and IQ in academic attainment. 

6. The effect of pramiracetam (CI-876) on the acquisition of radial arm maze task 

7. Memory training and drug therapy act differently on memory metamemory functioning: evidence from a pilot study. 

8. Nootropic drugs in Alzheimer’s disease; symptomatic treatment with pramiracetam

9. Safety of Pramiracetam.

10. Full-Text Excerpt of Smart Drugs & Nutrients – Section 4 – Pramiracetam.

11. Wellington Parc; Alzheimer’s FAQ