Oxiracetam is a nootropic drug and member of the ‘racetam family. While similar to Piracetam, Oxiracetam is much more potent. It improves many of the same mental processes as Piracetam, and is often taken by those looking for a more powerful alternative.


  • Improves the effectiveness of brain training games such as the ones offered by Lumosity.
  • Increases spatial learning and contextual learning [2]
  • Boosts memory [4][5]
  • Improves general cognitive functions [3]
  • Improves attentiveness, focus, and motivation [3]
  • Effective for the treatment of certain mental disorders including dementia, Alzheimer ’s disease, autism, and schizophrenia. [1]
  • Effective for repairing damage done by excessive alcohol consumption [4]

What Is Oxiracetam?

Oxiracetam is a water-soluble nootropic in the “racetam” family. Its effects are very similar to those of Piracetam and Aniracetam. Comparatively, many users report the effects of Oxiracetam to by much stronger and faster acting then both Piracetam and Aniracetam, however, results differ for everyone.

Medical Uses of Oxiracetam

Oxiracetam is not as widely prescribed for treating mental problems as other ‘racetams, however, there is still much research being conducted on its potential for treating Alzheimer’s Disease, dementia, and organic solvent abuse.

Oxiracetam is sometimes recommended to help fight cognitive decline due to aging. It’s cognitive benefits work against the symptoms of aging-related cognitive decline while its neuroprotective properties improve the physical health of the brain.

Using Oxiracetam

Like Aniracetam, Oxiracetam is often taken as a more potent alternative to Piracetam. Unlike Aniracetam, however, Oxiracetam is water-soluble. As a result, it doesn’t possess the same level of synergy with Piracetam that Aniracetam does. For most, it is best used as a replacement for Piracetam instead of a compliment to it.

How to Take Oxiracetam

The best ways to take Oxiracetam are in either capsules or in a bulk powder form. Capsules are far more convenient, but also more expensive. Like Piracetam, Oxiracetam mixes well with liquids, so mixing a proper dose of powder into a flavored drink such as orange juice is an easy way to take it. An even easier way to take powdered Oxiracetam is to purchase a Of course, if you are willing to invest in a capping machine. This will allow you to create your own Oxiracetam capsules at a much lower price than they can be purchased for.

Dosing Oxiracetam

Oxiracetam is usually sold in 800 mg tablets. It is recommended that you start with one 800 mg dose taken two or three times a day. Like with the other ‘racetams Oxiracetam is safe to take even at very high doses, however, it’s effectiveness will decline if taken at too high a dose.

How Does Oxiracetam Work?

Even though the exact mechanism of action is unknown, studies suggest that Oxiracetam affects the production of the neurotransmitters glutamate and acetylcholine.

Acetylcholine the only neurotransmitter used in the motor division of the somatic nervous system. It activates muscles in the peripheral nervous system and plays a very important role in our ability to sustain attention in the central nervous system. It also has a variety of effects as a neuromodulator upon plasticity meaning it affects our short-term memory and our ability to learn. [7]

Glutamate is a non-essential amino acid that plays an important role in memory formation, leaning, and sustaining neuron transmissions. [6]

Safety and Side Effects of Oxiracetam

Oxiracetam is regarded as being non-toxic and very safe. It can be taken daily without causing dependence, and use can be stopped without withdrawal symptoms.

There are no known side effects associated with prolonged use of Oxiracetam. Mild side effects that have been reported include insomnia and nausea, as well as mild headaches related to Choline deficiency.

Oxiracetam FAQ

Below are some of the most commonly asked questions about Oxiracetam. If you have a question that’s not on this list, send it to us at [email protected] and we will answer it for you.

Should I Take Oxiracetam?

Oxiracetam is a well proven, powerful nootropic that improves virtually all cognitive areas. Even though Oxiracetam is more potent than the other “racetams” it is also more expensive. If Piracetam and Aniracetam fail to meet expectations than Oxiracetam is an excellent choice.

How long does it take before I will feel the effects of Oxiracetam?

While Oxiracetam will affect everyone slightly differently, most people notice the effects of Oxiracetam extremely quickly. Unlike with Piracetam which can take weeks before its full benefits are realized, most people who try Oxiracetam feel it effects almost immediately.

How does Oxiracetam differ from the other ‘racetams?

Oxiracetam is water-soluble like Piracetam, and has a similar mechanism of action. What sets it apart is its much higher potency. Some people have reported getting a more stimulating effect from Oxiracetam, however, there is no research that attests to this.

Can I take Oxiracetam with other ‘racetams such as Piracetam?

Oxiracetam is completely safe to take with other ‘racetams and for that matter other nootropics. That said, it doesn’t appear to possess the strong synergy with Piracetam like Aniracetam does. While there is no reason Oxiracetam can’t be taken with other ‘racetams, it is probably best used as a more effective alternative to Piracetam.

Should I take Choline supplements with Oxiracetam?

While some people get enough Choline in their diets, others will need to supplement in order to avoid the side effect of mild headaches. If you experience these headaches you should supplement with Choline.The most commonly suggested ratio is 1:2. So if you take 1000mg of Oxiracetam, take 500mg of choline. If you are getting headaches then you should change your ratio to 1:1 (1000mg choline for ever 1000mg of Aniracetam). You may have to use a 1:1 ratio of you lack choline in your diet. A healthy adult should get around 500mg of choline each day through their diet.

Click here to view a list of foods with high concentrations of choline.

How long does a single dose of Oxiracetam last?

Oxiracetam has a half-life of 3-6 hours, so a single dose should produce last for at least 6 hours. In this regard it is far superior to Aniracetam, which only has a half-life of about 2 hours.

Is it possible to overdose on Oxiracetam?

There has never been a reported case of an overdose on Oxiracetam. Even in cases where extremely high doses of Oxiracetam have been consumed no serious side effects have been observed.

Is it safe to drink alcohol while on Oxiracetam?

It is completely safe to drink while taking Oxiracetam, however, some people report an intensification of alcohol’s effects when doing so. On the other hand, many people notice no difference in the effects of alcohol. If drinking while on Oxiracetam it is wise to start slow until you know how the combination will affect you.

Does Oxiracetam make a good study drug?

Oxiracetam’s powerful cognitive enhancing effects make it a great study aid, however, it will not produce the focus and motivation that popular study drugs such as Adderall will. Taking some Sulbutiamine as well will improve your mental stamina and give you increased “drive”

How can I tell if Oxiracetam is working for me?

The benefits of Oxiracetam should be noticeable very shortly after taking it. Because it doesn’t produce a “high” of any sort it may be difficult to immediately know if it is working, however, the results should be clear after trying any mentally strenuous task.

Can I take Oxiracetam every day?

Yes, Oxiracetam is not only safe to take every day, but is intended to be taken daily. Oxiracetam is not addictive, and its neuroprotective properties mean that long term use should improve the health of one’s brain.

What are some good alternatives to Oxiracetam?

If you want even stronger benefits, and want to stay inside the racetam family of nootropics give either Aniracetam or Pramiracetam a try. These are two ‘racetams that are well researched and more potent than Piracetam. If Oxiracetam’s effects are too pronounced, Piracetam will produce more subtle benefits.Other alternatives depend on what specific benefits you are looking for. For more information on what nootropics best meet specific needs, check out the Meet Your Goals entry on the main navigation bar at the top of this page.

Cited Studies

1. http://www.ncbi.nlm.nih.gov/pubmed/1603291

2. http://www.ncbi.nlm.nih.gov/pubmed?term=Enhancement%20of%20hippocampally-mediated%20learning%20and%20protein%20kinase%20C%20activity%20by%20oxiracetam%20in%20learning-impaired%20DBA%2F2%20mice

3. http://www.ncbi.nlm.nih.gov/pubmed?term=Treatment%20of%20cognitive%20impairment%20secondary%20to%20degenerative%20dementia.%20Effectiveness%20of%20oxiracetam%20therapy

4. http://www.ncbi.nlm.nih.gov/pubmed/1559636

5. http://www.sciencedirect.com/science/article/pii/S0166432800002989

6. Robert Sapolsky (2005). “Biology and Human Behavior: The Neurological Origins of Individuality, 2nd edition”. The Teaching Company. “see pages 19 and 20 of Guide Book

7. Himmelheber, AM; Sarter, M; Bruno, JP (2000). “Increases in cortical acetylcholine release during sustained attention performance in rats”. Brain research. Cognitive brain research 9 (3): 313–25. PMID 10808142